Current language model safety paradigms often fall short in emotionally charged or high-stakes settings, where refusal-only approaches may alienate users and naive compliance can amplify risk. We propose ProSocialAlign, a test-time, parameter-efficient framework that steers generation toward safe, empathetic, and value-aligned responses without retraining the base model. We formalize five human-centered objectives and cast safety as lexicographic constrained generation: first, applying hard constraints to eliminate harmful continuations; then optimizing for prosocial quality within the safe set. Our method combines (i) directional regulation, a harm-mitigation mechanism that subtracts a learned "harm vector" in parameter space, and (ii) preference-aware autoregressive reward modeling trained jointly across attributes with gradient conflict resolution, enabling fine-grained, user-controllable decoding. Empirical evaluations across five safety benchmarks demonstrate state-of-the-art performance, reducing unsafe leakage and boosting alignment to human values, with strong gains across multiple evaluation metrics. ProSocialAlign offers a robust and modular foundation for generating context-sensitive, safe, and human-aligned responses at inference time.

One in six laboratory-confirmed bacteria tested in 2023 proved resistant to antibiotic treatment, according to the World Health Organization. All were related to various common diseases. The proliferation of difficult-to-treat bacterial diseases represents a growing threat, according to the World Health Organization's (WHO) Global Antibiotic Resistance Surveillance Report. The report reveals that, between 2018 and 2023, antibiotic resistance increased by more than 40 percent in monitored pathogen-drug combinations, with an average annual increase of 5-15 percent. According to data reported by more than 100 countries to WHO's Global Antimicrobial Resistance and Use Surveillance System (GLASS), one in six laboratory-confirmed bacteria in 2023 proved resistant to antibiotic treatment, all related to various common diseases globally.

Tuberculosis remains a critical global health issue, particularly in resource-limited and remote areas. Early detection is vital for treatment, yet the lack of skilled radiologists underscores the need for artificial intelligence (AI)-driven screening tools. Developing reliable AI models is challenging due to the necessity for large, high-quality datasets, which are costly to obtain. To tackle this, we propose a teacher--student framework which enhances both disease and symptom detection on chest X-rays by integrating two supervised heads and a self-supervised head. Our model achieves an accuracy of 98.85% for distinguishing between COVID-19, tuberculosis, and normal cases, and a macro-F1 score of 90.09% for multilabel symptom detection, significantly outperforming baselines. The explainability assessments also show the model bases its predictions on relevant anatomical features, demonstrating promise for deployment in clinical screening and triage settings.

Infancy is characterized by rapid body growth and an explosive change of sensory and motor abilities. However, developmental robots and simulation platforms are typically designed in the image of a specific age, which limits their ability to capture the changing abilities and constraints of developing infants. To address this issue, we present MIMo v2, a new version of the multimodal infant model. It includes a growing body with increasing actuation strength covering the age range from birth to 24 months. It also features foveated vision with developing visual acuity as well as sensorimotor delays modeling finite signal transmission speeds to and from an infant's brain. Further enhancements of this MIMo version include an inverse kinematics module, a random environment generator and updated compatiblity with third-party simulation and learning libraries. Overall, this new MIMo version permits increased realism when modeling various aspects of sensorimotor development. The code is available on the official repository (https://github.com/trieschlab/MIMo).

The rapid evolution of artificial intelligence (AI), together with the increased availability of social media and news for epidemiological surveillance, are marking a pivotal moment in epidemiology and public health research. Leveraging the power of generative AI, we use an ensemble approach which incorporates multiple Large Language Models (LLMs) to extract valuable actionable epidemiological information from the World Health Organization (WHO) Disease Outbreak News (DONs). DONs is a collection of regular reports on global outbreaks curated by the WHO and the adopted decision-making processes to respond to them. The extracted information is made available in a daily-updated dataset and a knowledge graph, referred to as eKG, derived to provide a nuanced representation of the public health domain knowledge. We provide an overview of this new dataset and describe the structure of eKG, along with the services and tools used to access and utilize the data that we are building on top. These innovative data resources open altogether new opportunities for epidemiological research, and the analysis and surveillance of disease outbreaks.

As AI systems are increasingly deployed to support decision-making in critical domains, explainability has become a means to enhance the understandability of these outputs and enable users to make more informed and conscious choices. However, despite growing interest in the usability of eXplainable AI (XAI), the accessibility of these methods, particularly for users with vision impairments, remains underexplored. This paper investigates accessibility gaps in XAI through a two-pronged approach. First, a literature review of 79 studies reveals that evaluations of XAI techniques rarely include disabled users, with most explanations relying on inherently visual formats. Second, we present a four-part methodological proof of concept that opera-tionalizes inclusive XAI design: (1) categorization of AI systems, (2) persona definition and contex-tualization, (3) prototype design and implementation, and (4) expert and user assessment of XAI techniques for accessibility. Preliminary findings suggest that simplified explanations are more comprehensible for non-visual users than detailed ones, and that multimodal presentation is required for more equitable interpretability.

Modelling disease outbreak models remains challenging due to incomplete surveillance data, noise, and limited access to standardized datasets. We have created BIGBOY1.2, an open synthetic dataset generator that creates configurable epidemic time series and population-level trajectories suitable for benchmarking modelling, forecasting, and visualisation. The framework supports SEIR and SIR-like compartmental logic, custom seasonality, and noise injection to mimic real reporting artifacts. BIGBOY1.2 can produce datasets with diverse characteristics, making it suitable for comparing traditional epidemiological models (e.g., SIR, SEIR) with modern machine learning approaches (e.g., SVM, neural networks).

Clustering patient subgroups is essential for personalized care and efficient resource use. Traditional clustering methods struggle with high-dimensional, heterogeneous healthcare data and lack contextual understanding. This study evaluates Large Language Model (LLM) based clustering against classical methods using a pediatric sepsis dataset from a low-income country (LIC), containing 2,686 records with 28 numerical and 119 categorical variables. Patient records were serialized into text with and without a clustering objective. Embeddings were generated using quantized LLAMA 3.1 8B, DeepSeek-R1-Distill-Llama-8B with low-rank adaptation(LoRA), and Stella-En-400M-V5 models. K-means clustering was applied to these embeddings. Classical comparisons included K-Medoids clustering on UMAP and FAMD-reduced mixed data. Silhouette scores and statistical tests evaluated cluster quality and distinctiveness. Stella-En-400M-V5 achieved the highest Silhouette Score (0.86). LLAMA 3.1 8B with the clustering objective performed better with higher number of clusters, identifying subgroups with distinct nutritional, clinical, and socioeconomic profiles. LLM-based methods outperformed classical techniques by capturing richer context and prioritizing key features. These results highlight potential of LLMs for contextual phenotyping and informed decision-making in resource-limited settings.

The classification of clinical notes into specific diagnostic categories is critical in healthcare, especially for mental health conditions like Anxiety and Adjustment Disorder. In this study, we compare the performance of various Artificial Intelligence models, including both traditional Machine Learning approaches (Random Forest, Support Vector Machine, K-nearest neighbors, Decision Tree, and eXtreme Gradient Boost) and Deep Learning models (DistilBERT and SciBERT), to classify clinical notes into these two diagnoses. Additionally, we implemented three oversampling strategies: No Oversampling, Random Oversampling, and Synthetic Minority Oversampling Technique (SMOTE), to assess their impact on model performance. Hyperparameter tuning was also applied to optimize model accuracy. Our results indicate that oversampling techniques had minimal impact on model performance overall. The only exception was SMOTE, which showed a positive effect specifically with BERT-based models. However, hyperparameter optimization significantly improved accuracy across the models, enhancing their ability to generalize and perform on the dataset. The Decision Tree and eXtreme Gradient Boost models achieved the highest accuracy among machine learning approaches, both reaching 96%, while the DistilBERT and SciBERT models also attained 96% accuracy in the deep learning category. These findings underscore the importance of hyperparameter tuning in maximizing model performance. This study contributes to the ongoing research on AI-assisted diagnostic tools in mental health by providing insights into the efficacy of different model architectures and data balancing methods.

To enhance the accuracy and robustness of PM$_{2.5}$ concentration forecasting, this paper introduces FALNet, a Frequency-Aware LSTM Network that integrates frequency-domain decomposition, temporal modeling, and attention-based refinement. The model first applies STL and FFT to extract trend, seasonal, and denoised residual components, effectively filtering out high-frequency noise. The filtered residuals are then fed into a stacked LSTM to capture long-term dependencies, followed by a multi-head attention mechanism that dynamically focuses on key time steps. Experiments conducted on real-world urban air quality datasets demonstrate that FALNet consistently outperforms conventional models across standard metrics such as MAE, RMSE, and $R^2$. The model shows strong adaptability in capturing sharp fluctuations during pollution peaks and non-stationary conditions. These results validate the effectiveness and generalizability of FALNet for real-time air pollution prediction, environmental risk assessment, and decision-making support.